were the first to suggest that these particular vesicles were pre-lysosomes (Smith & Farquhar 1966). Pre-lysosomes form de novo in the cytoplasm from a cup-shaped membrane called a phagophore.

Trafficking occurs in both directions; the forward direction takes vesicles from the site of synthesis to the Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that have ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...

The autophagosome then fuses with another type of vesicle called a lysosome. The fused stage is called an autolysosome. The ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...