News

were the first to suggest that these particular vesicles were pre-lysosomes (Smith & Farquhar 1966). Pre-lysosomes form de novo in the cytoplasm from a cup-shaped membrane called a phagophore.
Trafficking occurs in both directions; the forward direction takes vesicles from the site of synthesis to the Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that have ...
The autophagosome then fuses with another type of vesicle called a lysosome. The fused stage is called an autolysosome. The ...
The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...
Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...
We found that Rab7, a protein present on the MVB’s outer membrane, is a regulator involved in dictating the fate of the vesicles. We believe that active Rab7 directs the EV toward the lysosomes, but ...
According to biology textbooks, a macrophage engulfs a bacterium, internalizes it in a toxin-filled vesicle called a phagosome, then shuttles the cellular remains to a lysosome for degradation. But ...
I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...