model compounds for various hepatic CYP isoenzymes, including phenacetin for CYP1A2, diclofenac for CYP2C9, bufuralol for CYP2D6, and midazolam for CYP3A4, were used to determine if atomoxetine ...

In the experimental model of hepatic injury produced by thioacetamide ... for hepatocytes only after having been activated by the CYP system. Inhibition of toxin bioactivation may contribute ...