When blood clots, the soluble protein fibrinogen is converted into insoluble fibrin by the action of thrombin. The molecular events of the process have been traced in considerable detail ...

and recombinant thrombin (which converts soluble fibrinogen into an insoluble three-dimensional fibrin matrix), and offers significant advantages over plasma-derived topical haemostat products ...

A fibrin clot, however, prepared from bovine fibrinogen is not resistant to trypsin or α-chymotrypsin in saline although it can be lysed more quickly by trypsin or α-chymotrypsin in 50 per cent ...