A seminal paper by Miller and Brody [1] clearly laid the general framework on why we should abandon the term "clinical equipoise" in research. Their paper argued that the concept of equipoise (also ...
Discordance in Human Epidermal Growth Factor Receptor 2 (HER2) Phenotype Between Primary Tumor and Circulating Tumor Cells in Women With HER2-Negative Metastatic Breast Cancer The ideas and opinions ...
It is not surprising that David Sackett1, 2 disagrees with Stanley Shapiro and Kathleen Glass;3 they are talking about different things. A clinical trial involves decisions at 3 distinct levels: that ...
The 2016 CIOMS International ethical guidelines for health‐related research involving humans states that ‘health‐related research should form an integral part of disaster response’ and that, ...
The investigators noted that the HYPERION trial had lost clinical equipoise based on robust evidence of clinical benefit from other trials. A phase 3 trial evaluating sotatercept-csrk (Winrevair™) in ...
Ironically, the proliferation of candidate drugs has often brought more angst than excitement. Faced with a positive result from an in vitro screen, researchers become entangled in a difficult ...
A phase 3 trial demonstrated shorter administration times with subcutaneous vs IV delivery of nivolumab with no significant difference in mRCC progression-free survival. Subcutaneous administration of ...
Robust evidence of the clinical benefit of WINREVAIR demonstrated in the STELLAR and ZENITH studies resulted in a loss of clinical equipoise in the HYPERION study RAHWAY, N.J., January 30, ...
Clinical trials in rheumatology are necessarily associated with an array of ethical issues that vary according to the type of trial under consideration. Difficult questions arise related to the ...
For more than a decade, the U.S. Preventive Services Task Force (USPSTF) [23] has published a ranking of clinical evidence. [24] The rankings, however, are based on what clinical investigators have ...
In a rebuttal to Stanley Shapiro and Kathleen Glass,1 David Sackett2 argues that a term such as “clinical equipoise” is useful only if it has a consistent meaning for everyone, describes something ...
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