Nevertheless, given the potential of siRNA as a therapy, this approach could pave the way for a new generation of treatments for numerous neurological diseases. Moreover, RVG-9R might not only be ...

Functional cure of chronic hepatitis B (CHB) remains a major clinical challenge. Current therapies—including nucleos(t)ide ...

More information: Yiliang Jin et al, Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma, Science Advances (2025). DOI: 10.1126 ...

SIL204 is a next-generation siRNA candidate targeting KRAS-driven cancers. In preclinical trials, a single administration of SIL-204 encapsulated in an extended-release formulation yielded tumor ...

today announced the publication of preclinical data in the journal Epilepsia demonstrating proof-of-mechanism of its investigational di-siRNA therapy, ATL-201, in a mouse model of KCNT1-related ...