Figure 4: Exact complementarity between the siRNA seed region and the 3′ UTR (but not 5′ UTR or ORF) distinguishes off-targeted from untargeted genes. The frequency at which we observed ...

Ui-Tei et al. 51 found that off-target effects are highly related to the thermodynamic properties of duplex formed between siRNA's seed region (the second to the eighth nucleotides from the 5 ...

A significant cause of these off-target effects is a seven-nucleotide region known as the seed region, located within the guide strand of the siRNA, which is critical for target recognition.

A significant cause of these off-target effects is a seven-nucleotide region known as the seed region, located within the guide strand of the siRNA, which is critical for target recognition. Off ...

No statistically significant enrichment for perfect matches between the EGFR siRNA seed region and 3’-UTRs of downregulated transcripts was observed in normal tissues. In tumor tissue ...

From that perch, the siRNA can act on the mRNA. The start-up recently closed a series A investment round that, when combined with its seed funding, comes out to $100 million. Atlas, the Column ...

The company has designed a drug candidate that combines a ligand with small interfering RNA (siRNA) that should silence ... when combined with its seed funding, comes out to $100 million.

We transfected siRNA targeting HIV-1 promoter region into a cell line productively infected with HIV-1. ChIP analysis revealed that the RNA duplex induced transcriptional gene silencing and enrichment ...

Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases. However, siRNA drugs have challenges because siRNAs often ...