How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing. A critical finding ...

Strong splice sites closely match consensus sequences and are efficiently recognized by the spliceosome, while weak or suboptimal splice sites may be skipped, leading to alternative splicing and ...

or mRNA, transcript that encodes protein. Alternative splicing is a process by which a cell can select which of those protein-coding parts to include in the resulting RNA or protein. Alternative ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

Researchers have rallied behind mechanisms such as alternative splicing, which may allow a lowly 30,000-gene genome to produce the dizzying variety of proteins that some believe is necessary to ...

Alternative splicing (AS) is a fundamental regulatory mechanism in messenger RNA (mRNA) processing, and abnormal splicing is a major cause of genetic disorders. To understand the genetic ...

In the most recent study, Lo followed up this observation from her previous paper to investigate the role of oncogenic KRAS in eliciting alternative mRNA splicing that might further drive ...

More information: Yang Pan et al, IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing, Proceedings of the National Academy of Sciences (2023). DOI ...

mRNA splicing is a fundamental part of the process that occurs when encoded DNA instructions are turned into a functional protein. After a gene is transcribed from DNA to RNA, extraneous sections ...

Upon heat stress, the double mutant of OsGRP3/OsGRP162 displayed globally reduced expression of heat-stress responsive genes and increased mRNA alternative splicing dominated by exon-skipping.

Alternative splicing (AS) is a fundamental regulatory mechanism in messenger RNA (mRNA) processing, and abnormal splicing is a major cause of genetic disorders. To understand the genetic ...