Recombinant human tripeptidyl peptidase 1 (cerliponase alfa) is an enzyme-replacement therapy that has been developed to treat neuronal ceroid lipofuscinosis type 2 (CLN2) disease, a rare ...

Tripeptidyl peptidase II (TPPII), an aminopeptidase with endoproteolytic activity, may also have a role in antigen processing. Here, we analyzed the processing and presentation of the ...

Giant proteases are homomultimeric assemblies of extraordinary size that act downstream of the proteasome. Moreover, they are capable of substituting for some of the proteasome's metabolic ...

Scientists have now uncovered the structure and the operating mechanism of an important component of the human cellular degradation machinery, tripeptidyl peptidase II (TPPII). Uncontrolled or ...

Latus Bio, Inc. has unveiled groundbreaking research on a novel adeno-associated virus (AAV) capsid variant, AAV-Ep+, which ...

The insights, thanks to the first molecular-scale description of a giant enzyme called tripeptidyl peptidase II, could also inform the development of obesity-fighting drugs. Scientists from the U ...

“Brineura is a recombinant human tripeptidyl peptidase enzyme. It is administered by intracerebral route through patented technology. The drug was indicated to slow loss of movement ability in ...

Also known as Batten disease, CLN2 is a progressive condition caused by the deficiency of the enzyme tripeptidyl peptidase 1. This results in the abnormal storage of proteins and lipids in neurons ...

A new study shows that delivery of gene therapy to correct the gene mutations that cause CLN2 disease, or Batten disease, directly into the cerebrospinal fluid (CSF) has potential therapeutic effects.

CLN2 is one of the most common forms of Batten disease caused by mutations in the tripeptidyl peptidase 1 (TPP1) gene. Last year, the FDA approved BioMarin Pharmaceutical’s TPP1 replacement ...

CLN2 disease is a fatal, childhood autosomal recessive disorder cause by mutations in the CLN2 gene, which encodes tripeptidyl peptidase (TPP-1). In a prior study, the investigators, Ronald ...