In both types, there is a buildup of a protein called transthyretin (TTR). TTR protein is made in the liver, brain, and retina of the eye. It helps to carry a thyroid hormone (thyroxine ...

progressive disease that causes a buildup of a protein called transthyretin (TTR). TTR protein is made in the liver, brain, and retina of the eye. It helps to carry a thyroid hormone (thyroxine ...

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy transthyretin moves hormones through blood and spinal fluid, misfolded ...

Transthyretin amyloidosis, also called ATTR amyloidosis, is associated with accumulation of ATTR amyloid deposits in the heart and commonly manifests as progressive cardiomyopathy. Patisiran, an ...

More information: Katsuya Nakamura et al, Genetic counselling for at-risk family members with hereditary transthyretin amyloidosis: data from a single-centre study, Amyloid (2024). DOI: 10.1080 ...

Transthyretin amyloid cardiomyopathy (ATTR-CM) can cause symptoms like shortness of breath, swelling in the legs, and fatigue. Treatment can include medication or liver and heart transplants ...

– EU approval based on NEURO-TTRansform Phase 3 results showing WAINZUA demonstrated consistent and sustained benefit improving neuropathy impairment and quality of life versus placebo ...

A report from the World Heart Federation provides an overview of transthyretin amyloid cardiomyopathy (ATTR-CM), including tools for diagnosis and patient management, highlighting the importance ...

Some 3 percent to 4 percent of Black individuals in the United States have the transthyretin V142I genetic variant, which significantly increases an individual’s risk of heart failure. The UAB-led ...