Formation of a molecular conjugate vector by conjugation of noninfective ... Moreover, conjugation to polylysine significantly enhances retroviral transduction of primitive HPC.

Therefore, we have chosen to use transduction efficiency by RTVsup stored at −196 °C as an internal standard, since storage at this temperature is expected to best preserve retroviral vector ...

In conclusion, the SIN γ-retrovirus vector was compatible with high-titer vector production in a clinical setting, with good transduction efficiencies overall, leading to transgene expression ...

Retroviral vector-mediated gene transfer has been central to the development of gene therapy. Retroviruses have several distinct advantages over other vectors, especially when permanent gene transfer ...

Retroviral vectors that are both non-replicating and non-integrating represent a novel and attractive tool that has potential advantages for gene delivery therapy, immunotherapy, and vaccinology.

Transduction of stem cells is generally ... autologous HSPCs that are genetically modified with the use of a γ-retroviral vector to insert a functional copy of the gene ADA.

However, for transduction to occur retrovirus cells require mitotic cell ... site is a significant inhibitory factor of this type of vector. It may lead to a disturbance in cellular function ...

More recently, the Vector Development Laboratory merged with our group, and we have expanded our services to offer AAV, first-generation adenovirus (FGAd), helper-dependent adenovirus (HDAd), ...

MxV-G pseudotyped vector not only enhances viral titer and transduction efficiency but also enables generated CAR-T cells to more effectively target and kill tumor cells. This novel envelope has ...

Transduction is the biological process by which DNA is transferred into a cell with the aid of a viral vector. This may take place naturally between bacterium via a bacteriophage in an example of ...

Monday, the FDA signed off on the Gilead subsidiary’s retroviral vector manufacturing facility in Oceanside, California, for commercial production of the much sought-after cell therapy component.

New research shows that an ancient retrovirus -- HK2 -- is more frequently found in drug addicts and thus is significantly associated with addiction. New research from an international team led by ...