The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

Why synonymous mutations are not always silent Modeling shows how genetic changes that don't lead to changes in protein sequence can still alter protein function Date: December 5, 2022 Source ...

"Because many biological conclusions rely on the presumption that synonymous mutations are neutral, its invalidation has broad implications. For example, synonymous mutations are generally ignored ...

A central assumption about so-called synonymous mutations, which are changes in the coding sequence of proteins that do not lead to changes in its amino acid sequence, is being questioned by a study ...

New research has indicated that so-called synonymous or silent mutations may actually be harmful. The findings, which used a yeast model, have been reported in Nature. If they are confirmed in humans, ...

Synonymous mutations have long been ignored in cancer studies since they don’t affect the amino acid sequences of proteins. But research increasingly reveals that they can have disease-driving effects ...

Gene mutations occur when one nucleotide in a codon is switched. In non-synonymous mutations, this disrupts the codon’s function to code for its amino acid. In synonymous mutations, the codon still ...

Now, research has also shown that silent mutations can also have an impact on physiology, in an unexpected way. This research, which was reported in the Proceedings of the National Academy of Sciences ...

Synonymous mutations are linked with changes in amino acids that are encoded by multiple codons. 9 Cell divisions are of two types: mitosis and meiosis. Mitosis occurs in somatic cells ...

The sperm of a man carrying a rare genetic mutation linked to cancer was used to conceive scores of children across Europe, ...