With base substitution mutations, only a single nucleotide within a gene sequence is changed, so only one codon is affected (Figure 1). Insertions and deletions are two other types of mutations ...

Tyrosine kinase inhibitors (TKIs) can treat EGFR exon 19 deletions and exon 21 (L858R) substitution mutations. Receptor tyrosine kinases like EGFR transmit signals from the surface of the cell to ...

The most common mutation (resulting in the R201H substitution) occurs within a CpG dinucleotide, a “hot spot” for mutations in mammalian genes. This probably explains the recurrent finding of ...

The Food and Drug Administration approved frontline Lazcluze plus Rybrevant for locally advanced or metastatic non-small cell lung cancer with an EGFR exon 19 deletions or exon 21 L858R substitution ...

or L858R substitution mutations. "Patients with EGFR-mutated non-small cell lung cancer deserve to live longer and with more hope than current treatments provide," said Yusri Elsayed, M.D., M.H.Sc., ...