Our services for retroviruses include production of viral supernatant by transient transfection as well as assay for replication competent retrovirus. Retroviral vector-mediated gene transfer has been ...

Comparison of human and other primate genomes provides evidence for a retroviral infection that bombarded the genomes of chimpanzees and gorillas 3-4 million years ago. It's been known for a long ...

Integrase is an essential retroviral enzyme that binds both termini of linear viral DNA and inserts them into a host cell chromosome. The structure of full-length retroviral integrase, either ...

However, to date little is known about vector stability. Therefore, we analyzed the stability of retroviral vectors produced in culture supernatants (RTVsup) for ex vivo gene therapy upon long ...

Retroviral vectors integrate stably into the host genome. The transgene in retroviral vectors is expressed long-term in the transduced cell and in its progeny. internal ribosome entry siteS or 2A ...

To achieve this, Gag binds to a region of the genomic RNA that, depending on the retrovirus, is about 100 to 300 nucleotides long and contains encapsidation signals. This region is therefore ...

Episodic antiretroviral therapy guided by the CD4+ count, as used in our study, significantly increased the risk of opportunistic disease or death from any cause, as compared with continuous ...

A new study shows that antiretroviral therapy given over two years was unable to completely restore age-appropriate epigenetic patterns, leaving patients more susceptible to aging-related illnesses.

HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have ...