Endosomal trafficking and protein sorting constitute fundamental processes that govern the intracellular localisation and recycling of membrane proteins in eukaryotic cells. Endosomes act as central ...

This study revealed two independent retrograde pathways: a sorting nexin–mediated pathway (orange) and a core retromer–mediated pathway (blue). In yeast, sorting nexins and the core retromer form a ...

Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients. These substances are first transported as cargo to the initial sorting compartment ...

"We now have a foundational data set that shows how protein dynamics change in normal heart development," said first author Whitney Edwards, Ph.D., and assistant professor in the UNC Department of ...

Blood flows around the body through a complex network of vessels, which must constantly adapt to changing needs. The balance ...

CHAPEL HILL, N.C. – Researchers at the UNC School of Medicine, UNC McAllister Heart Institute, and the UNC Lineberger Comprehensive Cancer Center characterized the expression of thousands of cardiac ...