"Our goal is to develop proteins with tailored functions ... But many amino acids have more than one possible codon; for instance, RNA reading the sequences UAU and UAC both correspond to the ...

“Our goal is to develop proteins with tailored functions ... However, many amino acids have more than one possible codon; for instance, RNA reading the sequences UAU and UAC both correspond ...

To synthesize functional proteins and avoid toxic translation products, the recognition of the correct initiation codon (AUG ... turn affect the evolution of sequences downstream of aATG.

This degeneracy provides a layer of protection against mutations, as some mutations in the third nucleotide of a codon may not change the amino acid that is specified. Protein synthesis begins with a ...

A change in the DNA sequence of a codon may not change the corresponding amino acid residue in the encoded protein because each residue can be encoded by several codons. This is called the Wobble ...

Therefore, there is an urgent need for a principled mRNA design algorithm that simultaneously optimizes stability and codon usage of encoding mRNA sequences to improve protein expression.

The key structural features of tRNA include: The specificity of tRNA-amino acid interactions and the accuracy of codon-anticodon recognition ensure the faithful translation of the genetic code into ...