KirBac channels are prokaryotic homologs of mammalian inwardly rectifying (Kir) potassium channels ... conformation and determined the crystal structure of this mutant channel to 3.05 Å resolution.

Figure 1: BK channel structure and specific potassium permeability. Two-thirds of the SLO protein sequence forms the large cytoplasmic C-terminal domain; we therefore assign the large particle ...

“BK is the first potassium channel I studied, so it is enormously satisfying to finally observe its molecular structure,” concluded MacKinnon. Below, check out an interview with him from earlier this ...

Since 1998, Roderick MacKinnon, head of molecular neurobiology and biophysics, Rockefeller University, and Howard Hughes Medical Institute (HHMI) investigator, and colleagues have published papers ...

opening in response to changes in membrane voltage and allowing potassium ions to escape. Hodgkin and Huxley laid out a model in 1952 for what voltage-gated channels might be doing, but their ...

Pore-forming proteins in living cells, termed ion channels, are embedded in the outer membrane of almost all cell types and ...

The image illustrates the structure of a potassium ion channel including the cytosolic domain (CTD), colored cyan, which is ...

The potassium ion channel, by contrast, is a tetramer, meaning its overall structure comprises four identical or similar subunits. These channels have only one pore encircled by the four parts.

Researchers have revealed the structure and function of a potassium ion channel in fruit flies. Their newly obtained insights reveal the differences between human and insect channels, explain how ...

joined forces with protein manufacturing company Cube Biotech and Bayer's Crop Science division to reveal the structure and function of a potassium ion channel from fruit flies. Their newly ...