The phagosome functions as more than just as an organelle for 'garbage disposal': proteins from the ingested target are degraded into peptides and presented on major histocompatibility complex ...

These assays provide functional insights into how the phagosome fulfils its diverse roles in homeostasis and in innate and adaptive immune responses. Figure 1: During maturation the phagosome ...

A phagosome can then fuse with other organelles that break down its contents. However, microglia and their organelles have been difficult to study because existing stem cell and animal models ...

To eliminate the threat and break it down to its constituents, the interior of the phagosome needs to be effectively and progressively acidified. For this crucial part of phagocytosis, the ...

Meet the phagosome. There are billions, perhaps even trillions, of these viruses, known as bacteriophages (“bacteria eaters” in Greek) or just “phages” to their friends, inside the human ...

These glycolipids prevent maturation of the host cell phagosome and may be a target for novel antimycobacterial drugs. Researchers at the Pasteur Institutes in Seoul and Paris, and at IPBS in ...

An ingested microbe or dead cell is engulfed in what is called a phagosome, a vesicle which is formed around the microbe by the cell membrane. This then fuses with a lysosome, another specialized ...

View Full Profile. Learn about our Editorial Policies. B.H. Abuaita et al., “Mitochondria-derived vesicles deliver antimicrobial reactive oxygen species to control phagosome-localized Staphylococcus ...

Mtb prevents the phagosome from merging with a lysosome, which otherwise would kill the bacteria. Instead, Mtb safely grows inside the phagosomes, then breaks out of the phagosomes into the cytosol of ...