Unfortunately, unlike animal studies, neuropathic pain mechanisms in humans remain largely unclear; current clinical and neurophysiological research has proposed various mechanisms for each type ...

in which pain is analyzed on the basis of underlying mechanisms. The increased knowledge of pain-generating mechanisms and their translation into symptoms and signs might eventually allow a ...

In a paper published in the journal Neuron, researchers report that a mechanism involving the enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord both initiates and maintains neuropathic ...

The detailed mechanism of how the placebo effect reduces the perception of pain in rats has been uncovered by RIKEN ...

“Advances in sensory neurobiology and neuroimmunology that are rapidly informing development of new therapies for pain will help to build on this foundational study toward a mechanism-based ...

In the proposed mechanism, pain signals still move from the body to the brain, but the individual does not feel as much ownership over those pain sensations, so their pain and suffering are reduced.

Morphine is a powerful painkiller that belongs to the group of opioids. It blocks signals in the pain pathways and also increases feelings of pleasure. Morphine acts on several central and ...

“The pain of a stubbed toe or a muscle cramp is often not minor,” Moseley said. “What might be the biological mechanism for why seemingly minor events and injuries are so painful?” ...

Convincing evidence now suggests that classifying neuropathic pain according to a mechanism-based rather than an etiology-based approach might help in targeting therapy to the individual patient ...