The protein p53 is often called the guardian of the genome for its central role in preventing cancer. Yet paradoxically, it ...
The transcription factor p53 is the most frequently inactivated tumour suppressor in cancer. Approaches to restore its wild-type function are challenging and have not led to approved drugs. An ...
A new therapy inspired by bacteria inside tumors cuts off cancer’s energy supply while largely leaving healthy cells ...
The tumor suppressor protein p53 plays a critical role in preventing cancer by regulating cell cycle, apoptosis, and genomic stability. However, mutations in the P53 gene are found in over 50% of ...
The utilization of patient-derived organoids as a platform for predicting the efficacy of anti-cancer drugs: Chemotherapy, targeted therapy, and immunotherapy. This is an ASCO Meeting Abstract from ...
A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...
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