Kappa-opioid receptor (KOR) agonists represent a promising class of compounds that modulate pain, mood and various neurobehavioural processes. Unlike traditional opioids that primarily target the ...
Opioid receptors are a subset of G protein–coupled receptors (GPCRs). These membrane proteins transmit signals into the cell ...
Two different versions of the mu-opioid receptor within a cellular membrane illustrate how the receptor changes its conformation to send a signal into the cell. Scientists captured six high-resolution ...
An internationally recognized leader in molecular pharmacology and neurobiology, Dr. Bohn recently joined USF Health. She is ...
Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...
Neuropeptide FF (NPFF) is an endogenous peptide that plays a critical role in modulating opioid receptor function. Its dual capacity to influence both opioid-induced analgesia and tolerance has ...
Mapping how Narcan reverses opioid overdose can provide a molecular blueprint for developing more effective drugs against overdose.
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Atomic swap in morphine core structure leads to safer, non-rewarding opioid alternative
One of the greatest revolutions in the field of pain medication was the isolation of morphine from the opium poppy in the 19th century. Morphine molecules act as painkillers by attaching themselves to ...
An experimental compound (gold) binds (dotted lines) to an unconventional spot within opioid receptors (turquoise) in the brain and therefore avoids some of the dangers associated with current opioid ...
Researchers identified the structure of an opioid receptor in the brain during active engagement with a drug molecule. The discovery could facilitate the creation of safer and more effective opioid ...
University of Florida scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional ...
Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose.
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