Aptamers, which belong to a class of small molecule ligands composed of short single-stranded oligonucleotides, have emerged as probes over the last several decades; however, their potential ...

The technology uses molecular beacons or fluorogenic oligonucleotide signaling probes directed to target genes. Probes are designed to form stem-loop structures with a fluorophore and quencher paired ...

Oligonucleotides can be used as probes to detect specific DNA or RNA sequences through hybridization. These probes are often labeled with fluorescent dyes or other reporter molecules for detection.

PCR’s ability to generate high concentrations of a specific labeled DNA target created a paradigm shift in oligonucleotide probe hybridization analysis. Previously, target DNA had been ...

In contrast to RT-PCR, which measures average RNA transcript levels for a population of cells, sm-FISH targets individual transcripts with many short (~20 bases) oligonucleotide probes. Researchers ...

The gold standard for 5′ nuclease qPCR assays is set by three critical features in oligonucleotide probes: fluorescent reporter dyes, quenchers for these dyes, and a minor groove binder.

Oligonucleotides are short nucleic acid polymers used in research, genetic testing and forensics. Oligonucleotides are usually made up of 13 to 25 nucleotides and are designed to hybridize ...

Probes are an important subsegment in the market for synthesized oligonucleotides. The segment accounted for the second-largest market share of the synthesized oligonucelotide market. This is due ...

The gold standard for 5′ nuclease qPCR assays is set by three critical features in oligonucleotide probes: fluorescent reporter dyes, quenchers for these dyes, and a minor groove binder. MGB Eclipse ...

Performing Real-Time qPCR with the 5’ fluorogenic nuclease assay and a Double-Dye oligonucleotide probe provides additional specificity during PCR amplification, an essential component for a ...