The Ohio-based biotech entrepreneur has emerged as a leading contender to succeed Vice President-elect JD Vance in the U.S. Senate.

Ohio Gov. Mike DeWine’s frontrunner for the vacancy is Lt. Gov. Jon Husted — not Ramaswamy, Republican operatives told The Post.

Gov. Mike DeWine must pick someone to replace Vice President-elect JD Vance, who resigned his Senate seat last week.

The co-leader of the “Department of Government Efficiency” could move to replace JD Vance in the Senate, though other contenders remain.

President-elect Donald Trump has privately encouraged Vivek Ramaswamy to consider an appointment to the US Senate seat recently vacated by Vice President-elect JD Vance if offered the position by Ohio Gov.

The Department of Government Efficiency's first order of business was itself: It's now down to one leader. Vivek Ramaswamy is no longer part of the commission that President Donald Trump championed, officials confirmed hours after the Republican took office Monday,

WASHINGTON (TNND) — Vivek Ramaswamy will no longer be a part of President Donald Trump's Department of Government Efficiency (DOGE) after he signaled plans to run for governor of Ohio, according to officials. The decision leaves billionaire Elon Musk to run the cost-cutting operation alone.

Trump's DOGE initiative seeks to streamline federal operations, dismantle bureaucracy and fire nonessential federal employees.