Leptin-deficient (ob/ob) mice are obese and infertile. Dysfunctions of the ovaries are preferentially related to leptin-deficiency. Ovaries were obtained from three-month-old mice either ...

However, RYGB failed to generate the same effects in leptin-deficient ob/ob mice, which suffered a weight regain over the pre-surgery level. In ob/ob mice, body weight was reduced by RYGB ...

Eight-week-old female ob/ob mice received daily intraperitoneal injections of vehicle (six mice), 0.2 μg of nonmutant leptin per gram of body weight (six mice), or 0.2 μg of D100Y leptin per ...

They also conducted similar experiments on ob/ob mice that were genetically programmed to exhibit leptin dysfunction. Leptin—a hormone synthesized by fat cells—controls satiety and energy ...

In that study, the researchers used the 3D data to identify changes in the Islets of Langerhans in the obese (ob/ob) mice. This animal model is often used to study initial metabolic changes that ...

They also conducted similar experiments on ob/ob mice that were genetically programmed to exhibit leptin dysfunction. Leptin - a hormone synthesized by fat cells - controls satiety and energy ...

As a result, it was found that obese/diabetic model (Ob/Ob) mice had a significantly lower survival rate than wild-type mice. In addition, two days after infection, large amounts of virus were ...