Acute myeloid leukemia (AML) has a dismal prognosis, with a 5 year overall survival of ~30% [1]. The poor outcomes are in part due to AML being a heterogeneous disease, with substantial variability ...

In simple terms: a mutation is a stable change in genetic sequence that can be copied when cells or viruses replicate. Most mutations have no detectable effect, some contribute to disease, and a small ...

Immunoscore Is Prognostic in Low-Risk and High-Risk Stage III Colon Carcinomas Treated With Adjuvant Infusional Fluorouracil, Leucovorin, and Oxaliplatin in a Phase III Trial Patients who underwent ...

Occasionally, single-letter misspellings in the genetic code, known as point mutations, occur. Point mutations that alter the resulting protein sequences are called nonsynonymous mutations, while ...

Mantle cell lymphoma (MCL) is a rare and commonly aggressive subtype of B-cell lymphoma characterized by the translocation t(11;14) with consecutive cyclin D1 overexpression. The clinical course is ...