More information: Takuya Hidaka et al, Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation, Cell Chemical Biology (2021).

One DNA sequence would be repeated over and over ... their bodies a mixture of cells with and without the mutated sequence. Only some of the chimeras will have reproductive organs that make ...

CRISPR, which offers an easy way to snip out mutated DNA and replace it with the correct sequence, holds potential for treating many genetic disorders, according to the research team. Using a new ...

Mutant DNA sequences inside cellular mitochondria can ... In some mitochondrial diseases, mutated DNA and normal DNA co-exist. “This state is called heteroplasmy,” explains Kyoto University ...

The study highlights the ability of mutagenic compounds to also affect the process of transcription, during which a DNA sequence is converted (or transcribed) to mRNA, an intermediary stage ...

Their findings are published in the journal Cell Chemical Biology in a paper titled, “Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence ...

The intrinsic promoter activity of the WPRE was detectable only in constructs lacking other promoter sequences and was ... the native or mutated forms can be used equivalently.

The small study in patients with a rare disorder that causes liver and lung damage showed the potential for precisely targeted infusions. By Gina Kolata Researchers have corrected a disease ...

Thus, nonsense mutations occur when a premature nonsense or stop codon is introduced in the DNA sequence. When the mutated sequence is translated into a protein, the resulting protein is ...

The “search” sequence finds its target, a mutated sequence. The Cas domain nicks one DNA strand, liberating a 3’ DNA flap, which pairs to a complementary portion of the “replace ...

Delivering three RNA guide strands, along with Cas9 and the correct DNA sequence for the mutated gene, they managed to insert the correct gene in about one of every 250 cells in the livers of mice.