These systems, called large language ... of amino acids within proteins and used the system's internal representation of what it learned to extract information about the structure of those proteins.

The AI tool AlphaFold has been improved so that it can now predict the shape of very large and complex protein structures. Linköping University researchers have also succeeded in integrating ...

Much of the difficulty of determining the contributions of individual residues to protein structure and function stems from the need to generate and evaluate a large number of mutants. The ...

In a new move, researchers have shown that protein design software can incorporate motion into its outputs. The resulting ...

The AI tool AlphaFold has been improved so that it can now predict the shape of very large and complex protein structures. Linköping University researchers have also succeeded in integrating ...

an international public research institute that already hosts a large database of protein information. The latest data release gives the database a massive boost. The update includes structures ...

Meta’s AI model is a new protein-folding approach inspired by large language models that aims to predict the structures of the hundreds of millions of protein sequences in metagenomics databases.

BaseFold leverages Basecamp Research's purpose-built foundational dataset to significantly increase prediction accuracy of large, complex protein structures and small molecule interactions — it ...

Instead, they saw unfamiliar large complexes made up of multiple strands of the same RNA—structures they didn't know were possible without the support of proteins. Two of the RNAs assembled into ...

If the structure is impaired at just one specific point, the protein can no longer fulfill its function. In the human body, ...

we generated a large number of these protein–DNA complexes and treated them with enzymes that destroy unfolded proteins. The intact proteins, which were able to maintain their folded structures ...