Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...
Replication forks encounter problems due to causes such as chemical damage to the DNA template, from both endogenous and exogenous agents, and problems with the protein–DNA complexes that are ...
When the replication machinery copies DNA, it must unwind the double helix in one direction while synthesis of one of the strands proceeds in the other. Making transient DNA loops may solve this ...
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