Although many of the crystals that living creatures produce inside their cells are comprised of just two molecules—guanine and hypoxanthine—the resultant diversity is mind-boggling in terms of ...

The proposed transition state for hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) has been used to design and synthesize powerful inhibitors that contain features of the transition state.

Hypoxanthine and xanthine are intermediate steps in this transition. Assessing their prevalence in meat indicates its freshness. The freshness of animal meat is an essential property determining ...

Allopurinol and its principal metabolic product, oxipurinol (alloxanthine, oxoallopurinol), inhibit the enzyme, xanthine oxidase, that normally converts hypoxanthine to xanthine, and xanthine to ...

The condition occurs due to issues with the enzyme known as hypoxanthine-guanine phosphoribosyltransferase (HPRT), which results in the accumulation of uric acid. Lesch-Nyhan syndrome is an X ...