The proposed transition state for hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) has been used to design and synthesize powerful inhibitors that contain features of the transition state ...

Identification of hypoxanthine and phosphoenolpyruvic acid as serum markers associated with chemoradiotherapy response in locally advanced rectal cancer. Authors: Min-Jeong Kim, Byong Chul Yoo, and ...

SINCE its clinical introduction in 1964, allopurinol (4-hydroxypyrazolo-[3,4-d]-pyrimidine) has been increasingly used for the treatment of hyperuricemia of gout,1 , 2 many neoplastic diseases and ...

It occurs due to a problem with the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). The condition predominantly affects males as it is an X-linked recessive condition.