Huntington’s disease is part of a group of neurodegenerative disorders associated with gene mutations that disturb normal brain development and function. Although the mechanisms behind these ...

A defect in a single gene, the huntingtin (HTT) gene, causes Huntington’s disease. That said, the genetic mutation is different from many other mutations. There isn’t a substitution or a ...

Researchers have implicated a new gene in the progression of Huntington's disease in a brain organoid ... Moreover, "the organoid model suggests that HTT mutations damage brain development even ...

Genetic mutations occur everyday in our cells, but the vast majority of them are repaired. New research finds DNA repair is not on PAR in HD cells, causing mutations to build up in people with HD.

For 30 years, researchers have known that Huntington's is caused by an inherited mutation ... helps the cell monitor its DNA ...

Researchers have made a major breakthrough in our understanding of Huntington's disease. This genetic disorder has long been known to be caused by mutations in the huntingtin gene, which leads to the ...

Huntington's disease (HD), an autosomal-dominant progressive neurological disease with an identified gene mutation, has demonstrated insidious changes in brain morphology, motor control ...

CAMBRIDGE, Massachusetts ‒ For decades it's been one of the defining mysteries of Huntington's disease ... on their family in the interim. If the mutations accumulate slowly, symptoms might ...

HD is a rare, adult-onset, autosomal dominant, progressive neurodegenerative disease. George Huntington (Figure ... of the HTT gene and its mutations will continue into the future as we search ...

This systematic review and meta-analysis of the prevalence and incidence of Huntington’s disease (HD ... of HD is the occurrence of de novo HD mutations (which account for an estimated 7.1 ...

These disorders are termed Huntington's disease-like (HDL) syndromes. So far, four such conditions have been recognized, namely disorders attributable to mutations in the prion protein gene (HDL1 ...

Huntington’s disease (HD) is an inherited neurological condition that happens when a gene mutation causes toxic proteins to collect in different parts of the brain. HD, also known as Huntington ...