found that removing Hippo signaling did not impair the ability of the studied organs to grow to their normal size. What’s more, the authors found that the transcriptional activity of Yap/Taz/Yki ...

known as the Hippo-YAP/TAZ signaling pathway, that plays a dominant role in the formation and maintenance of LNs. Their findings have been reported in the journal Nature Communications.

The HIPPO pathway's regulation of YAP/TAZ activity can either suppress or promote EMT, depending on the cellular context. The TGF-β and HIPPO signaling pathways are integral to liver physiology ...

A downstream Hippo signaling pathway transcriptional coactivator and Yes-associated protein (YAP) homolog, WWTR1/TAZ, was significantly downregulated in COVID-19. SARS-CoV-2 genomes were detected ...

This study establishes a mechanistic link between obesity-altered metabolism and dysregulated proteasomal pathways, specifically the YAP-mediated Hippo cascade. Results show that the Hippo signaling ...

5-hydroxymethylcytosine as a liquid biopsy biomarker in colorectal cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium. This abstract does not include a full ...

Three years after coming of out stealth, Vivace Therapeutics has raised another $30 million to pursue drugs targeting the Hippo-YAP pathway ... that inhibit the Hippo signaling pathway and ...

It is known that the Hippo/YAP signaling pathway plays a crucial role in cell proliferation and tumorigenesis; is thought to contribute to 10% of all cancer types. TYK Medicines Inc. has presented a ...

The pig cardiomyocyte cells also showed upregulation of three signaling pathways -- the Mitogen-Activated Protein Kinase pathway, the HIPPO/YAP pathway and the Transforming Growth Factor Β pathway.

Yang and her team at HSDM have spent years studying cell signaling. One of the pathways they focus on is the Hippo/YAP pathway—a signaling pathway crucial for regulating cell growth related to ...