At first glance, the result seems surprising, since the enzyme blockade inhibits the sugar degradation pathway in both cases.

Glycolysis takes place in the cytoplasm. Within the mitochondrion, the citric acid cycle occurs in the mitochondrial matrix, and oxidative metabolism occurs at the internal folded mitochondrial ...

The researchers’ RNA-seq experiments didn’t show increased gene expression of any of the enzymes involved in glycolysis, except hexokinase, which performs the first step. Levels of lactate, a product ...