Malignancy is associated with altered expression of glycans and glycoproteins that contribute to the cellular glycocalyx. We constructed a glycoprotein expression signature, which revealed that ...

and reduced tumor growth in breast cancer mouse models. Mucinases clear the glycoprotein branches within the glycocalyx forest, reversing mucin’s multifaceted physical and immunological functions.

By understanding the role of the glycocalyx, scientists may discover better ways to get medicines into the brain, offering hope for conditions ranging from multiple sclerosis to brain cancer. For now, ...

This matrix, known as the glycocalyx, differs depending on the type of cell. It serves, so to speak, as an identifier for the body cells. This means that to capture a specific bacterium ...