which in turn bind to regulatory sites in the DNA that effectively block RNA polymerase binding (Figure 3). The control of gene expression in eukaryotes is more complex than that in prokaryotes.

This valuable study investigates how stochastic and deterministic factors are integrated during cellular decision-making, particularly in situations where cells differentiate into distinct fates ...

classification (Figure 1B). Clusters 7, 8, 11, and 14 were not associated with a FAB subtype but had distinct gene-expression profiles. Overall survival, event-free survival, and relapse rates ...

Complex traits are influenced by genes and the environment, but especially the latter is difficult to pin down. This important study uses C. elegans to demonstrate that non-genetic differences in gene ...

We conclude by discussing the possibility that stochasticity in gene expression is an evolvable trait, and the growing evidence for a role of stochasticity in development and disease. Figure 1 ...

Researchers still do not have a comprehensive picture of the factors that influence gene expression in human cancers.

But the grammar of CREs has been hard to figure out, “with no straightforward ... for designing genetic switches that precisely tune gene expression for novel applications, such as ...

Sizeable differences in gene expression means and ratios—based solely upon where genes are located on a plasmid (gene syntax)—have been discovered by researchers at Dartmouth College.

Get Instant Summarized Text (Gist) Generative AI has been used to design synthetic DNA regulatory sequences that precisely control gene expression in healthy mammalian cells. These AI-generated ...

Researchers measure gene expression by observing the amount of mRNA a specific gene produces. As scientists began to understand the role of the genome as life's blueprint, they thought that ...

It also includes searching for mutated genes that confer a unique vulnerability to cancer cells and studying gene expression patterns that are associated with mutation status across all tumor types. A ...