Gap junctions are specialised intercellular channels that facilitate direct communication between adjacent cells by allowing the regulated exchange of ions, second messengers and small metabolites.

Ischemia reperfusion injury (IRI) is one of the main cause of organ dysfunction after heart attack and solid organ transplantation, and occurs frequently when the new organ comes from a deceased ...

Signaling through gap junctions (electrical synapses) is important in the development of the mammalian central nervous system. Abundant between neurons during postnatal development, gap junction ...

When two cells "talk" to each other, they often do so through tiny channels called electrical synapses. Unlike chemical synapses, these so-called gap junctions enable the direct exchange of ...

TNBCs rely on fatty acid oxidization (FAO) to fuel tumor growth by breaking down surrounding adipose tissue through lipolysis. Gap junctions, particularly involving GJB3 and connexin 31 (Cx31), ...

A new study by the University of California, Davis, shows how cells work together to avoid a sudden drop in blood sugar. Understanding these feedback loops could improve the lives of people with ...

Researchers at the University of California, San Francisco (UCSF) have found that cells from triple-negative breast cancer (TNBC) form direct connections with nearby fat cells to access energy needed ...

Neighboring cells exchange molecular information via channels that directly connect them. Disruption of this signaling system can lead to disorders ranging from hearing loss to heart disease Like ...

Adeno-associated virus vector containing an adenine base editor provides an effective strategy to treat hereditary hearing loss caused by the R75W mutation. Moreover, this gene editing technology can ...