1 Denaturation: Double-stranded DNA separates into single strands ... The recommended final concentration is 1-10 percent. Formamide weakens base pairing and increases primer annealing specificity, ...

Formamide interferes with these hydrogen bonds, leading to destabilization of the helical structure of the mRNA, causing denaturation or separation of the strands. Without strand formation ...

The work “nicely correlates the Late Heavy Bombardment and the energy that it delivered to Earth with the formation of RNA and DNA nucleobases from formamide”, says Steven Benner at the ...