Folate, otherwise known as vitamin B9, acts as a one-carbon cofactor for deoxyribonucleic acid (DNA) synthesis, repair, and methylation. It participates in interconnected folate and methionine cycles ...
DHFR: dihydrofolate reductase; FH2: dihydrofolic acid; FH4: tetrahydrofolic acid; MTHFD: methylenetetrahydrofolate dehydrogenase; SHMT: hydroxymethyltransferase ...
Deficient dietary folate intake may be associated with increased cancer risk in humans owing to DNA damage resulting from impaired nucleotide excision repair. It is conceivable that an association ...
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