The findings, published in Nature Communications, highlight the potential therapeutic benefit of drugs such as methotrexate, which inhibit folate and one-carbon metabolic pathways appropriated by ...

which inhibits the folate and the one-carbon metabolic pathways appropriated by the virus. The researchers also demonstrated that while intracellular glucose and folate are depleted in the SARS ...

Phenytoin does not seem to have any effect on the folate metabolism pathways, nor does it appear to affect the excretion of folate. 27 However, most antiseizure medications increase hepatic ...

Folate is a vitamin cofactor required as a one-carbon (1C) donor in multiple metabolic pathways. Its role is within the folate-mediated one-carbon metabolism (FOCM). This network of reactions ...

A comprehensive panel of mutation scanning assays detects mutations in the APC, TP53, KRAS, BRAF genes and hypermethylated APC and MLH1 DNA in plasma of patients with various stages of colorectal ...

These negative outcomes may stem from disruptions in the one-carbon (1C) metabolic pathway, including impaired folic acid receptor function and altered enzyme expression. However, more ...

Since methylfolate is further along the metabolic pathway than folinic acid, the risks of methylfolate may be lower. Second, folic acid competes with methylfolate at folate receptors, so a high ...

While the level of improvement across all participants was modest, results were more significant in individuals carrying specific variants in genes involved with folate metabolism. Adding the ...

Well, several drugs (such as valproic acid and lamotrigine** used in seizures and bipolar disorder) interfere with the metabolism of folic acid to the final form that is most active in the brain ...