Epigenetic modulation has emerged as a pivotal regulator of tumour immunity, governing both cancer cell immunogenicity and the functional state of immune effectors within the tumour microenvironment.

Epigenetic modulation encompasses reversible alterations to the chromatin landscape that regulate gene expression without changing the underlying DNA sequence. In glioblastoma, a highly aggressive ...

Cellular findings show Telomir-Zn modulates intracellular metal balance linked to oxidative stress, mitochondrial dysfunction, DNA methylation instability, and genomic integrity-without relying on ...

Real world experience of FGFR gene alterations and clinical outcomes in advanced/metastatic urothelial cancer in Japan: MONSTAR-SCREEN database study. Performance of a tumor-informed molecular ...

Epigenetics, a term coined by Conrad H. Waddington in the early 1940s, originally described the complex molecular pathways that govern how a genotype manifests as a phenotype. Over time, this ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH ...

Higher TAGLN2 gene activity may contribute to the development of pulmonary arterial hypertension (PAH), according to a new ...