A protein called PriC allows DNA replication to proceed in Escherichia coli when the complex that usually initiates this process is compromised.

A key player on this stage is an enzyme called a helicase. Its job is to unwind the tightly coiled chain of nucleic acids – the DNA or RNA molecule that spells out the organism’s genetic code ...

Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen interacting with DNA, the laboratories of KAUST Assistant Professor Alfredo De Biasio ...

Published online on Aug. 10 in Nucleic Acids Research, the paper focuses on the DNA damage response pathway and demonstrates how this pathway can reduce the function of a viral enzyme, a helicase, ...

Using cutting edge cryo-electron microscopy, the team of scientists were able to visualise a helicase enzyme (nature's DNA unzipping machine) in the process of unwinding DNA. DNA helicases are ...

The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

Using cutting edge cryo-electron microscopy, the team of scientists were able to visualise a helicase enzyme (nature's DNA unzipping machine) in the process of unwinding DNA. DNA helicases are ...

Like other DNA damage response therapies, RO7589831 inhibits the function of a DNA repair enzyme, in this case Werner helicase, to create a buildup of DNA damage within tumor cells, ultimately ...

ATX-559, a first-in-class oral DHX9 inhibitor, is being evaluated in a Phase 1/2 study with a focuson advanced or metastatic ...

WRN is a helicase required for DNA replication and DNA repair and is a validated target for tumors with microsatellite instability (MSI). Nimbus will present preclinical data on NTX-452 ...

which involves site-directed deposition of the DNA helicase, DHX36. The new study, published in the Journal of Neuroscience, provides the first evidence that G4-DNA is present in neurons and ...