Cre-loxP organisms are generally produced by separately creating Cre-lineage and loxP-lineage individuals that contain the Cre gene and loxP in their genome, respectively, and then crossing them ...

When Cre recombinase (red circle) is introduced, either as a transgene by crossing into a mouse line carrying the targeted gene locus or on a viral vector, the DNA between the loxP sites (red ...

Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...