Wnt signalling encompasses a family of secreted glycoproteins that orchestrate skeletal formation, remodelling and repair through two principal routes: the canonical (β-catenin-dependent) pathway and ...

Wnt signalling comprises a network of pathways essential to embryonic development, tissue patterning and stem cell maintenance. The canonical branch centres on the stabilization of β-catenin, which ...

Targeting the WNT signaling pathway represents a promising strategy for cancer therapy. The field has evolved to include numerous inhibitors currently under preclinical and clinical investigation.

Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in the world, and its incidence and mortality have increased year by year. HCC research has increasingly focused on ...