The aberrant activation of B cells plays a central role in the pathogenesis of various autoimmune diseases and B-cell lymphomas. Now, Honigberg and colleagues describe an orally available ...

According to Kahlenberg, although B-cell activation is “important for many patients” with lupus, treatment needs to be tailored and individualized. For example, belimumab (Benlysta ...

More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038 ...