Co-activation of IFN, TLR7 and BCR pathways induces normal B cells to achieve SLE-like status ... Total RNA was extracted by using the RNeasy kit according to the instructions of the manufacture ...

B-cell acute lymphoblastic leukemia (B-ALL) is the most common cancer in children, accounting for around 85% of pediatric ...

B-cell activation was followed by expansion of circulating ... RNA was extracted with the PAXgene RNA kit and was purified in accordance with the manufacturer’s protocols, with the exception ...

According to Kahlenberg, although B-cell activation is “important for many patients” with lupus, treatment needs to be tailored and individualized. For example, belimumab (Benlysta ...

The researchers have examined the earliest step in activating the B cells, namely the activation mechanism that is triggered when the cells recognise a specific target or 'enemy' -- an antigen.

Chimeric antigen receptor (CAR) T cells ... B-cell lymphomas. 1-9 These therapies incorporate either a 4-1BB (CD137) or a CD28 intracellular costimulatory domain to enhance T-cell activation ...