Figure 3: PINK1 recruits OPTN and NDP52 independently of parkin to promote mitophagy. Through the genetic knockout of five autophagy receptors, we have defined their relative roles in mitophagy ...

The new research suggests why HSV-1 is suppressed: OPTN, a conserved autophagy receptor, selectively targets HSV-1 proteins to degradation by autophagy, explained Tejabhiram Yadavalli, a co-author ...

Using various molecular biology techniques, the team found that deleting the gene encoding TBK1 prevented the association of an autophagy adaptor called optineurin (OPTN) during Parkin-mediated ...

Using various molecular biology techniques, the team found that deleting the gene encoding TBK1 prevented association of an autophagy adaptor called optineurin (OPTN) during Parkin-mediated ...

Autophagy (“self-eating”) is the process ... autophagosomes acquire SNAP receptor (SNARE) proteins such as syntaxin 17 (STX17) and YKT6, which interact with SNAP29 and lysosomal SNARE proteins ...

The ATG8s include the light chain 3 (LC3) subfamily and the γ-aminobutyric acid receptor-associated protein (GABARAP) subfamily. The key signals that initiate the autophagy cascade are those that ...