I don't know if the combination of Doomguy and Isabelle, Animal Crossing's extremely lovable mayoral secretary, has quite hit meme status yet. But as rounded up in this Resetera thread ...

The love between these two fanbases began with a crossover from the DOOM Subreddit, with reddit user Genkiz-_ (with art by Popzotz) reaching out to r/AnimalCrossing with a message of support ...