The alternative splicing regulatory network is modulated by functional coupling between transcription and RNA processing. The transcription machinery can influence alternative splicing decisions ...

Alternative splicing (AS) is a major contributor to transcriptome and proteome diversity. Evolutionary studies help to address questions that are fundamental to understanding this important process.

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease. Cohesin is known to play a key part in transcription ...

Researchers have rallied behind mechanisms such as alternative splicing, which may allow a lowly 30,000-gene genome to produce the dizzying variety of proteins that some believe is necessary to ...

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs - single-stranded RNAs involved in protein synthesis - and proteins from the same stretch of DNA ...

Alternative splicing is crucial for eukaryotic gene expression and influences protein function and regulation, with mis-splicing linked to numerous diseases. In this webinar, Dr. Megan L Noonan will ...

In a study published on 28 May 2024 in Nature Communications, researchers from Tokyo Medical and Dental University (TMDU) in Japan revealed significant new insights into alternative splicing and ...

A study published Wednesday (March 1) in Science Advances suggests that cohesin regulates alternative splicing—the phenomenon when coding regions of a gene are combined in different ways during ...

An important process that modifies RNA sequences is alternative splicing, whereby specific sequences within the RNA molecule may be rearranged, included or excluded. This process results in ...

SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. (“Biosplice”), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing ...