Cre-loxP organisms are generally produced by separately creating Cre-lineage and loxP-lineage individuals that contain the ...

A new editorial paper has been published in Oncoscience, titled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." In this editorial, researchers Piotr Czarnota ...

Another limitation of the Cre-loxP method includes its current inability to specifically direct Cre to certain types of EVs (for example, between exosomes, microvesicles and even larger membrane ...

The resulting experimental mouse is hemizygous for Cre and homozygous for loxP (D). This is the necessary genotype required to conditionally knock out the target gene in the specific tissue. Laura is ...

The enzyme Cre (cyclization recombination) recombinase targets and cuts a DNA sequence and catalyzes recombination with another DNA locus (loxP). When a cell containing loxP sites in its genome ...

All our multiexpression systems (currently MultiBac, MultiMam and MultiColi) rely on in vitro Cre-loxP recombination of Acceptor and Donor plasmids to assemble multiprotein expression vectors. A ...

The Yong Xu lab is interested in novel neural circuits, neurotransmitters and intra-neuronal signals that are critical for coordinated control of metabolism and behavior. We generate unique mouse ...

The Wang lab is interested in brain estrogenic actions in the regulation of energy and glucose balance under different physiological conditions, including: Sex differences in response to nutritional ...

Organisms modified via the introduction of the Cre-loxP system (Cre-loxP organisms) are widely used in life sciences to investigate the function of specific genes.Cre is a type of DNA ...

A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." In this new ...